DRD4 Antibody (PACO06418)
- SKU:
- PACO06418
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | DRD4 Antibody (PACO06418) |
抗体コード: | PACO06418 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:40000, WB:1:500-1:2000, IF:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from the C-terminal region of human D4DR. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of K562 cells using D4DR Polyclonal Antibody. | |
Western Blot analysis of K562 cells using D4DR Polyclonal Antibody. |
シノニム: | DRD4; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor |
UniProt Protein Function: | DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; protein binding; SH3 domain binding Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; response to amphetamine; synaptic transmission, dopaminergic Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait |
NCBI Summary: | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008] |
UniProt Code: | P21917 |
NCBI GenInfo Identifier: | 1345939 |
NCBI Gene ID: | 1815 |
NCBI Accession: | P21917.2 |
UniProt Secondary Accession: | P21917,Q7Z7Q5, Q8NGM5, B0M0J7, |
UniProt Related Accession: | P21917 |
Molecular Weight: | 48,361 Da |
NCBI Full Name: | D(4) dopamine receptor |
NCBI Synonym Full Names: | dopamine receptor D4 |
NCBI Official Symbol: | DRD4 |
NCBI Official Synonym Symbols: | D4DR |
NCBI Protein Information: | D(4) dopamine receptor |
UniProt Protein Name: | D(4) dopamine receptor |
UniProt Synonym Protein Names: | D(2C) dopamine receptor; Dopamine D4 receptor |
Protein Family: | D(4) dopamine receptor |
UniProt Gene Name: | DRD4 |
UniProt Entry Name: | DRD4_HUMAN |
Antibodies | ELISA Kits |
Anti-DRD4 Antibody (CAB1337) | Human D4R/DRD4 (Dopamine Receptor D4) ELISA Kit (HUES02295) |
Anti-DRD4 Antibody (CAB2894) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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