DNTT Antibody (PACO02593)
- SKU:
- PACO02593
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DNTT Antibody |
抗体コード: | PACO02593 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human |
免疫原: | synthesized peptide derived from the Internal region of human TdT. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | DNTT; TDT; DNA nucleotidylexotransferase; Terminal addition enzyme; Terminal deoxynucleotidyltransferase; Terminal transferase |
UniProt Protein Function: | DNTT: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. Belongs to the DNA polymerase type-X family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.7.7.31; Transferase Chromosomal Location of Human Ortholog: 10q23-q24 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:DNA nucleotidylexotransferase activity; protein binding Biological Process: DNA metabolic process |
NCBI Summary: | This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | P04053 |
NCBI GenInfo Identifier: | 311033533 |
NCBI Gene ID: | 1791 |
NCBI Accession: | P04053.3 |
UniProt Secondary Accession: | P04053,Q53FH1, Q5W103, Q96E50, |
UniProt Related Accession: | P04053 |
Molecular Weight: | 58,408 Da |
NCBI Full Name: | DNA nucleotidylexotransferase |
NCBI Synonym Full Names: | DNA nucleotidylexotransferase |
NCBI Official Symbol: | DNTT |
NCBI Official Synonym Symbols: | TDT |
NCBI Protein Information: | DNA nucleotidylexotransferase |
UniProt Protein Name: | DNA nucleotidylexotransferase |
UniProt Synonym Protein Names: | Terminal addition enzyme; Terminal deoxynucleotidyltransferase; Terminal transferase |
Protein Family: | DNA nucleotidylexotransferase |
UniProt Gene Name: | DNTT |
UniProt Entry Name: | TDT_HUMAN |