DNAJA1 Antibody (PACO16507)
- SKU:
- PACO16507
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | DNAJA1 Antibody (PACO16507) |
抗体コード: | PACO16507 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human DNAJA1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16507(DNAJA1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: HepG2 cells, Raji cells, A431 cells, 231 cells, Primary antibody: PACO16507(DNAJA1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16507(DNAJA1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling. |
シノニム: | DnaJ (Hsp40) homolog, subfamily A, member 1 |
UniProt Protein Function: | DNAJA1: Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria. |
UniProt Protein Details: | Protein type:Chaperone; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: membrane; mitochondrion; perinuclear region of cytoplasm; cytosol; nucleus; ubiquitin ligase complex Molecular Function:protein binding; G-protein-coupled receptor binding; low-density lipoprotein receptor binding; chaperone binding; metal ion binding; ubiquitin protein ligase binding; unfolded protein binding; Hsp70 protein binding; ATP binding Biological Process: negative regulation of JNK activity; protein folding; positive regulation of apoptosis; DNA damage response, detection of DNA damage; response to unfolded protein; regulation of protein transport; sperm motility; response to heat; androgen receptor signaling pathway; spermatogenesis; protein refolding; negative regulation of protein ubiquitination; negative regulation of apoptosis |
UniProt Code: | P31689 |
NCBI GenInfo Identifier: | 1706474 |
NCBI Gene ID: | 3301 |
NCBI Accession: | P31689.2 |
UniProt Secondary Accession: | P31689,Q5T7Q0, Q86TL9, |
UniProt Related Accession: | P31689 |
Molecular Weight: | 397 |
NCBI Full Name: | DnaJ homolog subfamily A member 1 |
NCBI Synonym Full Names: | DnaJ (Hsp40) homolog, subfamily A, member 1 |
NCBI Official Symbol: | DNAJA1 |
NCBI Official Synonym Symbols: | DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2 |
NCBI Protein Information: | dnaJ homolog subfamily A member 1; HSJ-2; human DnaJ protein 2; heat shock protein J2; dnaJ protein homolog 2; heat shock 40 kDa protein 4; heat shock protein, DNAJ-like 2; neural precursor cell expressed, developmentally down-regulated 7 |
UniProt Protein Name: | DnaJ homolog subfamily A member 1 |
UniProt Synonym Protein Names: | DnaJ protein homolog 2; HSDJ; Heat shock 40 kDa protein 4; Heat shock protein J2; HSJ-2; Human DnaJ protein 2; hDj-2 |
UniProt Gene Name: | DNAJA1 |
UniProt Entry Name: | DNJA1_HUMAN |
Antibodies |
Anti-DNAJA1 Antibody (CAB11602) |
Anti-DNAJA1 Antibody (CAB19865)[KO Validated] |
DNAJA1 Antibody (PACO01876) |
DNAJA1 Antibody (PACO08870) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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