DLL4 Antibody, HRP conjugated (PACO48883)
- SKU:
- PACO48883
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | DLL4 Antibody, HRP conjugated (PACO48883) |
抗体コード: | PACO48883 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Delta-like protein 4 protein (44-345AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate. |
シノニム: | Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4), DLL4 |
UniProt Protein Function: | DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: angiogenesis; blood circulation; blood vessel remodeling; negative regulation of cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; Notch receptor processing; Notch signaling pathway; patterning of blood vessels; positive regulation of Notch signaling pathway; signal transduction; T cell differentiation Disease: Adams-oliver Syndrome 6 |
NCBI Summary: | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NR61 |
NCBI GenInfo Identifier: | 13431490 |
NCBI Gene ID: | 54567 |
NCBI Accession: | Q9NR61.1 |
UniProt Secondary Accession: | Q9NR61,Q3KP23, Q9NQT9, |
UniProt Related Accession: | Q9NR61 |
Molecular Weight: | 75kDa |
NCBI Full Name: | Delta-like protein 4 |
NCBI Synonym Full Names: | delta like canonical Notch ligand 4 |
NCBI Official Symbol: | DLL4 |
NCBI Official Synonym Symbols: | AOS6; hdelta2 |
NCBI Protein Information: | delta-like protein 4 |
UniProt Protein Name: | Delta-like protein 4 |
UniProt Synonym Protein Names: | Drosophila Delta homolog 4; Delta4 |
Protein Family: | Delta-like protein |
UniProt Gene Name: | DLL4 |