UniProt Protein Function: | Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. |
NCBI Summary: | This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011] |
UniProt Code: | Q12959 |
NCBI GenInfo Identifier: | 223590196 |
NCBI Gene ID: | 1739 |
NCBI Accession: | Q12959.2 |
UniProt Secondary Accession: | Q12959,Q12958, A5YKK7, B4DGU1, B4DGZ8, B7ZMM0, B9EIQ5 D3DXB8, D3DXB9, E7EWL7, E9PG21, |
UniProt Related Accession: | Q12959 |
Molecular Weight: | 100kDa |
NCBI Full Name: | Disks large homolog 1 |
NCBI Synonym Full Names: | discs large MAGUK scaffold protein 1 |
NCBI Official Symbol: | DLG1 |
NCBI Official Synonym Symbols: | hdlg; DLGH1; SAP97; SAP-97; dJ1061C18.1.1 |
NCBI Protein Information: | disks large homolog 1 |
UniProt Protein Name: | Disks large homolog 1 |
UniProt Synonym Protein Names: | Synapse-associated protein 97; SAP-97; SAP97; hDlg |
Protein Family: | Disks large |
UniProt Gene Name: | DLG1 |