DKK4 Antibody (PACO14343)
- SKU:
- PACO14343
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DKK4 Antibody (PACO14343) |
抗体コード: | PACO14343 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Fusion protein of human DKK4 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14343(DKK4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14343(DKK4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. |
シノニム: | dickkopf WNT signaling pathway inhibitor 4 |
UniProt Protein Function: | DKK4: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family. |
UniProt Protein Details: | Protein type:Inhibitor; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8p11.2-p11.1 Cellular Component: extracellular region Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; multicellular organismal development |
NCBI Summary: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBT3 |
NCBI GenInfo Identifier: | 13124092 |
NCBI Gene ID: | 27121 |
NCBI Accession: | Q9UBT3.1 |
UniProt Secondary Accession: | Q9UBT3,Q3KNX0, Q9Y4C3, |
UniProt Related Accession: | Q9UBT3 |
Molecular Weight: | 24,876 Da |
NCBI Full Name: | Dickkopf-related protein 4 |
NCBI Synonym Full Names: | dickkopf WNT signaling pathway inhibitor 4 |
NCBI Official Symbol: | DKK4 |
NCBI Official Synonym Symbols: | DKK-4 |
NCBI Protein Information: | dickkopf-related protein 4 |
UniProt Protein Name: | Dickkopf-related protein 4 |
Protein Family: | Dickkopf-related protein |
UniProt Gene Name: | DKK4 |
UniProt Entry Name: | DKK4_HUMAN |
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