DKK2 Antibody, HRP conjugated (PACO32569)
- SKU:
- PACO32569
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | DKK2 Antibody, HRP conjugated (PACO32569) |
抗体コード: | PACO32569 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Dickkopf-related protein 2 protein (34-259AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
シノニム: | Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2), DKK2 |
UniProt Protein Function: | DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 4q25 Cellular Component: extracellular space |
NCBI Summary: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBU2 |
NCBI GenInfo Identifier: | 13124093 |
NCBI Gene ID: | 27123 |
NCBI Accession: | Q9UBU2.1 |
UniProt Secondary Accession: | Q9UBU2,Q9UIU3, A0AVE9, B2R6S7, |
UniProt Related Accession: | Q9UBU2 |
Molecular Weight: | 28,447 Da |
NCBI Full Name: | Dickkopf-related protein 2 |
NCBI Synonym Full Names: | dickkopf WNT signaling pathway inhibitor 2 |
NCBI Official Symbol: | DKK2 |
NCBI Official Synonym Symbols: | DKK-2 |
NCBI Protein Information: | dickkopf-related protein 2 |
UniProt Protein Name: | Dickkopf-related protein 2 |
Protein Family: | Dickkopf-related protein |
UniProt Gene Name: | DKK2 |
UniProt Entry Name: | DKK2_HUMAN |