DHX36 Antibody (PACO49282)
- SKU:
- PACO49282
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DHX36 Antibody (PACO49282) |
抗体コード: | PACO49282 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human ATP-dependent RNA helicase DHX36 protein (68-181AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of U251 cells using PACO49282 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. |
シノニム: | ATP-dependent RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAH box protein 36) (G4-resolvase 1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE), DHX36, DDX36 KIAA1488 MLEL1 RHAU |
UniProt Protein Function: | DHX36: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.6.4.13; EC 3.6.4.12; Helicase; RNA-binding Chromosomal Location of Human Ortholog: 3q25.2 Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleus Molecular Function:G-quadruplex DNA binding; DNA-dependent ATPase activity; protein binding; histone deacetylase binding; double-stranded RNA binding; ATP-dependent RNA helicase activity; ATP binding Biological Process: RNA processing; ossification; response to exogenous dsRNA; transcription, DNA-dependent; response to virus; RNA secondary structure unwinding; positive regulation of telomere maintenance; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H2U1 |
NCBI GenInfo Identifier: | 313104099 |
NCBI Gene ID: | 170506 |
NCBI Accession: | Q9H2U1.2 |
UniProt Secondary Accession: | Q9H2U1,Q70JU3, Q8IYE5, Q9P240, B2RB00, |
UniProt Related Accession: | Q9H2U1 |
Molecular Weight: | 1008 |
NCBI Full Name: | ATP-dependent RNA helicase DHX36 |
NCBI Synonym Full Names: | DEAH (Asp-Glu-Ala-His) box polypeptide 36 |
NCBI Official Symbol: | DHX36 |
NCBI Official Synonym Symbols: | G4R1; RHAU; DDX36; MLEL1 |
NCBI Protein Information: | ATP-dependent RNA helicase DHX36; G4 resolvase-1; G4-resolvase 1; MLE-like protein 1; DEAH box protein 36; probable ATP-dependent RNA helicase DHX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; RNA helicase associated with AU-rich element ARE |
UniProt Protein Name: | ATP-dependent RNA helicase DHX36 |
UniProt Synonym Protein Names: | DEAH box protein 36; G4-resolvase 1; G4R1; MLE-like protein 1; RNA helicase associated with AU-rich element ARE |
Protein Family: | ATP-dependent RNA helicase |
UniProt Gene Name: | DHX36 |
UniProt Entry Name: | DHX36_HUMAN |