DDIT4 Antibody (PACO16162)
- SKU:
- PACO16162
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DDIT4 Antibody (PACO16162) |
抗体コード: | PACO16162 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human DDIT4 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16162(DDIT4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16162(DDIT4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness. |
シノニム: | DNA-damage-inducible transcript 4 |
UniProt Protein Function: | DDIT4: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: cytoplasm; cytosol; intracellular Biological Process: brain development; cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of peptidyl-serine phosphorylation; negative regulation of TOR signaling pathway; nerve growth factor receptor signaling pathway; neuron differentiation; neuron migration; response to hypoxia |
UniProt Code: | Q9NX09 |
NCBI GenInfo Identifier: | 74753036 |
NCBI Gene ID: | 54541 |
NCBI Accession: | Q9NX09.1 |
UniProt Secondary Accession: | Q9NX09,Q9H0S3, |
UniProt Related Accession: | Q9NX09 |
Molecular Weight: | 25,371 Da |
NCBI Full Name: | DNA damage-inducible transcript 4 protein |
NCBI Synonym Full Names: | DNA damage inducible transcript 4 |
NCBI Official Symbol: | DDIT4 |
NCBI Official Synonym Symbols: | Dig2; REDD1; REDD-1 |
NCBI Protein Information: | DNA damage-inducible transcript 4 protein |
UniProt Protein Name: | DNA damage-inducible transcript 4 protein |
UniProt Synonym Protein Names: | HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1 |
Protein Family: | DNA damage-inducible transcript 4 protein |
UniProt Gene Name: | DDIT4 |
UniProt Entry Name: | DDIT4_HUMAN |
Antibodies | ELISA Kits |
Anti-DDIT4 Antibody (CAB14135) | Human REDD1 (Protein regulated in development and DNA damage response 1) ELISA Kit (HUFI08548) |
Anti-DDIT4 Antibody (CAB8086)[KO Validated] |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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