DAAM1 Antibody (PACO19540)
- SKU:
- PACO19540
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DAAM1 Antibody (PACO19540) |
抗体コード: | PACO19540 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human DAAM1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19540(DAAM1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO19540(DAAM1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19540(DAAM1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. |
シノニム: | dishevelled associated activator of morphogenesis 1 |
UniProt Protein Function: | DAAM1: Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 14q23.1 Cellular Component: cytoplasm; cytosol; membrane; plasma membrane; stress fiber Molecular Function:identical protein binding; protein binding Biological Process: Wnt receptor signaling pathway, planar cell polarity pathway |
NCBI Summary: | Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q9Y4D1 |
NCBI GenInfo Identifier: | 34098767 |
NCBI Gene ID: | 23002 |
NCBI Accession: | Q9Y4D1.2 |
UniProt Secondary Accession: | Q9Y4D1,Q86U34, Q8N1Z8, Q8TB39, |
UniProt Related Accession: | Q9Y4D1 |
Molecular Weight: | 100,745 Da |
NCBI Full Name: | Disheveled-associated activator of morphogenesis 1 |
NCBI Synonym Full Names: | dishevelled associated activator of morphogenesis 1 |
NCBI Official Symbol: | DAAM1 |
NCBI Protein Information: | disheveled-associated activator of morphogenesis 1 |
UniProt Protein Name: | Disheveled-associated activator of morphogenesis 1 |
Protein Family: | Disheveled-associated activator of morphogenesis |
UniProt Gene Name: | DAAM1 |
UniProt Entry Name: | DAAM1_HUMAN |