CYP4F12 Antibody (PACO43969)
- SKU:
- PACO43969
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CYP4F12 Antibody (PACO43969) |
抗体コード: | PACO43969 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human Cytochrome P450 4F12 protein (265-524AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CYP4F12 antibody at 6µg/ml. Lane 1: Mouse small intestine tissue. Lane 2: Rat liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 61, 12 kDa. Observed band size: 61 kDa. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43969 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO43969 at dilution of 1:100. |
バックグラウンド: | Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid, omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine. |
シノニム: | Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12), CYP4F12 |
UniProt Protein Function: | CYP4F12: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine. Belongs to the cytochrome P450 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; EC 1.14.13.30; Membrane protein, multi-pass; Oxidoreductase Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: apical plasma membrane; cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bound organelle Molecular Function:alkane 1-monooxygenase activity; arachidonic acid epoxygenase activity; leukotriene-B4 20-monooxygenase activity; oxygen binding Biological Process: arachidonic acid metabolic process; drug metabolic process; epoxygenase P450 pathway; long-chain fatty acid metabolic process; pressure natriuresis; renal water homeostasis; sodium ion homeostasis; very-long-chain fatty acid metabolic process; vitamin E metabolic process |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
UniProt Code: | Q9HCS2 |
NCBI GenInfo Identifier: | 313104094 |
NCBI Gene ID: | 66002 |
NCBI Accession: | Q9HCS2.2 |
UniProt Secondary Accession: | Q9HCS2,O60389, Q5JPJ7, Q9HCS1, E7ET51, |
UniProt Related Accession: | Q9HCS2 |
Molecular Weight: | 11,572 Da |
NCBI Full Name: | Cytochrome P450 4F12 |
NCBI Synonym Full Names: | cytochrome P450 family 4 subfamily F member 12 |
NCBI Official Symbol: | CYP4F12 |
NCBI Official Synonym Symbols: | CYPIVF12; F22329_1 |
NCBI Protein Information: | cytochrome P450 4F12 |
UniProt Protein Name: | Cytochrome P450 4F12 |
UniProt Synonym Protein Names: | CYPIVF12 |
Protein Family: | Cytochrome |
UniProt Gene Name: | CYP4F12 |
UniProt Entry Name: | CP4FC_HUMAN |