CYP17A1 Antibody (PACO16114)
- SKU:
- PACO16114
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CYP17A1 Antibody (PACO16114) |
抗体コード: | PACO16114 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Fusion protein of human CYP17A1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16114(CYP17A1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16114(CYP17A1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. |
シノニム: | cytochrome P450, family 17, subfamily A, polypeptide 1 |
UniProt Code: | P05093 |
NCBI GenInfo Identifier: | 117283 |
NCBI Gene ID: | 1586 |
NCBI Accession: | P05093.1 |
UniProt Secondary Accession: | P05093,Q5TZV7, |
UniProt Related Accession: | P05093 |
Molecular Weight: | 57,371 Da |
NCBI Full Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
NCBI Synonym Full Names: | cytochrome P450 family 17 subfamily A member 1 |
NCBI Official Symbol: | CYP17A1 |
NCBI Official Synonym Symbols: | CPT7; CYP17; S17AH; P450C17 |
NCBI Protein Information: | steroid 17-alpha-hydroxylase/17,20 lyase |
UniProt Protein Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
UniProt Synonym Protein Names: | 17-alpha-hydroxyprogesterone aldolase (EC:1.14.14.321 PublicationManual assertion based on experiment iniRef.10"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001."DeVore N.M., Scott E.E.Nature 482:116-119(2012) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 24-508 IN COMPLEXES WITH HEME; ABIRATERONE AND TOK-001, FUNCTION, CATALYTIC ACTIVITY, COFACTOR. |
Protein Family: | Steroid 17-alpha-hydroxylase/17,20 lyase |
UniProt Gene Name: | CYP17A1 |
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