UniProt Protein Function: | TORC3: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N- terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription. Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. Belongs to the TORC family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:cAMP response element binding protein binding Biological Process: activation of CREB transcription factor; macrophage activation; positive regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q6UUV7 |
NCBI GenInfo Identifier: | 167009130 |
NCBI Gene ID: | 64784 |
NCBI Accession: | Q6UUV7.2 |
UniProt Secondary Accession: | Q6UUV7,Q6DK61, Q6DK62, Q8NF38, Q9H6U2, |
UniProt Related Accession: | Q6UUV7 |
Molecular Weight: | 66,830 Da |
NCBI Full Name: | CREB-regulated transcription coactivator 3 |
NCBI Synonym Full Names: | CREB regulated transcription coactivator 3 |
NCBI Official Symbol: | CRTC3 |
NCBI Official Synonym Symbols: | TORC3; TORC-3 |
NCBI Protein Information: | CREB-regulated transcription coactivator 3 |
UniProt Protein Name: | CREB-regulated transcription coactivator 3 |
UniProt Synonym Protein Names: | Transducer of regulated cAMP response element-binding protein 3; TORC-3; Transducer of CREB protein 3 |
Protein Family: | CREB-regulated transcription coactivator |
UniProt Gene Name: | CRTC3 |