CREB3L2 Antibody (PACO43715)
- SKU:
- PACO43715
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CREB3L2 Antibody (PACO43715) |
抗体コード: | PACO43715 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 2 protein (1-247AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CREB3L2 antibody at 6µg/ml. Lane 1: Mouse liver tissue. Lane 2: Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 58, 51, 28 kDa. Observed band size: 58 kDa. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43715 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43715 at dilution of 1:100. |
バックグラウンド: | Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity). |
シノニム: | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2], CREB3L2, BBF2H7 |
UniProt Protein Function: | CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 7q33 Cellular Component: endoplasmic reticulum; nucleoplasm; nucleus Biological Process: cartilage development; chondrocyte differentiation; positive regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q70SY1 |
NCBI GenInfo Identifier: | 296439387 |
NCBI Gene ID: | 64764 |
NCBI Accession: | Q70SY1.3 |
UniProt Secondary Accession: | Q70SY1,Q6P454, Q6ZMR6, |
UniProt Related Accession: | Q70SY1 |
Molecular Weight: | 57kDa |
NCBI Full Name: | Cyclic AMP-responsive element-binding protein 3-like protein 2 |
NCBI Synonym Full Names: | cAMP responsive element binding protein 3 like 2 |
NCBI Official Symbol: | CREB3L2 |
NCBI Official Synonym Symbols: | BBF2H7 |
NCBI Protein Information: | cyclic AMP-responsive element-binding protein 3-like protein 2 |
UniProt Protein Name: | Cyclic AMP-responsive element-binding protein 3-like protein 2 |
UniProt Synonym Protein Names: | BBF2 human homolog on chromosome 7 |
Protein Family: | Cyclic AMP-responsive element-binding protein 3-like protein |
UniProt Gene Name: | CREB3L2 |
Antibodies | ELISA Kits |
Anti-CREB3L2 Antibody (CAB10554) | CREB3L2 Transcription Factor Activity Assay |
CREB3L2 Antibody (PACO06376) | |
CREB3L2 Antibody (PACO08592) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |