CRADD Antibody, HRP conjugated (PACO25918)
- SKU:
- PACO25918
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | CRADD Antibody, HRP conjugated (PACO25918) |
抗体コード: | PACO25918 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Death domain-containing protein CRADD protein (1-199AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. |
シノニム: | Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain), CRADD, RAIDD |
UniProt Protein Function: | CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Apoptosis Chromosomal Location of Human Ortholog: 12q21.33-q23.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding, bridging; protein binding; protease binding Biological Process: caspase activation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Disease: Mental Retardation, Autosomal Recessive 34 |
NCBI Summary: | This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
UniProt Code: | P78560 |
NCBI GenInfo Identifier: | 2498833 |
NCBI Gene ID: | 8738 |
NCBI Accession: | P78560.1 |
UniProt Related Accession: | P78560 |
Molecular Weight: | ~ 23kDa |
NCBI Full Name: | Death domain-containing protein CRADD |
NCBI Synonym Full Names: | CASP2 and RIPK1 domain containing adaptor with death domain |
NCBI Official Symbol: | CRADD |
NCBI Official Synonym Symbols: | MRT34; RAIDD |
NCBI Protein Information: | death domain-containing protein CRADD |
UniProt Protein Name: | Death domain-containing protein CRADD |
UniProt Synonym Protein Names: | Caspase and RIP adapter with death domain; RIP-associated protein with a death domain |
UniProt Gene Name: | CRADD |
UniProt Entry Name: | CRADD_HUMAN |