CR1 Antibody (PACO19505)
- SKU:
- PACO19505
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CR1 Antibody (PACO19505) |
抗体コード: | PACO19505 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human CR1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19505(CR1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19505(CR1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. |
シノニム: | complement component (3b/4b) receptor 1 (Knops blood group) |
UniProt Protein Function: | CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q32 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; complement component C3b binding Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway Disease: Knops Blood Group System; Malaria, Susceptibility To |
NCBI Summary: | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | P17927 |
NCBI GenInfo Identifier: | 86793036 |
NCBI Gene ID: | 1378 |
NCBI Accession: | NP_000564.2 |
UniProt Secondary Accession: | P17927,Q16744, Q16745, Q5SR43, Q5SR45, Q9UQV2, |
UniProt Related Accession: | P17927 |
Molecular Weight: | 223,663 Da |
NCBI Full Name: | complement receptor type 1 isoform F |
NCBI Synonym Full Names: | complement component (3b/4b) receptor 1 (Knops blood group) |
NCBI Official Symbol: | CR1 |
NCBI Official Synonym Symbols: | KN; C3BR; C4BR; CD35 |
NCBI Protein Information: | complement receptor type 1 |
UniProt Protein Name: | Complement receptor type 1 |
UniProt Synonym Protein Names: | C3b/C4b receptor; CD_antigen: CD35 |
Protein Family: | Complement receptor |
UniProt Gene Name: | CR1 |
UniProt Entry Name: | CR1_HUMAN |
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