COLEC11 Antibody (PACO43973)
- SKU:
- PACO43973
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | COLEC11 Antibody (PACO43973) |
抗体コード: | PACO43973 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Collectin-11 protein (26-271AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: COLEC11 antibody at 4µg/ml + Rat liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 29, 27, 22, 30, 25, 24, 31 kDa. Observed band size: 29 kDa. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43973 at dilution of 1:100. |
バックグラウンド: | Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity). |
シノニム: | Collectin-11 (Collectin kidney protein 1) (CL-K1), COLEC11 |
UniProt Protein Function: | Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481). |
NCBI Summary: | This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9BWP8 |
NCBI GenInfo Identifier: | 13128972 |
NCBI Gene ID: | 78989 |
NCBI Accession: | NP_076932 |
UniProt Related Accession: | Q9BWP8 |
Molecular Weight: | 28.665 |
NCBI Full Name: | collectin-11 isoform a |
NCBI Synonym Full Names: | collectin subfamily member 11 |
NCBI Official Symbol: | COLEC11 |
NCBI Official Synonym Symbols: | 3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb |
NCBI Protein Information: | collectin-11 |
UniProt Protein Name: | Collectin-11 |
UniProt Synonym Protein Names: | Collectin kidney protein 1; CL-K1 |
Protein Family: | Collectin |
UniProt Gene Name: | COLEC11 |
Antibodies | ELISA Kits |
Anti-COLEC11 Antibody (CAB4955) | Human COLEC11 ELISA Kit |
COLEC11 Antibody (PACO08517) | Human Collectin-11 (COLEC11) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |