COL4A2 Antibody (PACO33152)
- SKU:
- PACO33152
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | COL4A2 Antibody (PACO33152) |
抗体コード: | PACO33152 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Collagen alpha-2(IV) chain protein (1493-1712AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO33152 at dilution of 1:50. |
バックグラウンド: | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen α 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. |
シノニム: | Collagen alpha-2(IV) chain [Cleaved into: Canstatin], COL4A2 |
UniProt Protein Function: | COL4A2: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A2 are the cause of porencephaly type 2 (POREN2). POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH). ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the type IV collagen family. |
UniProt Protein Details: | Protein type:Secreted; Extracellular matrix; Secreted, signal peptide Chromosomal Location of Human Ortholog: 13q34 Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; collagen type IV; extracellular region Molecular Function:protein binding; extracellular matrix structural constituent Biological Process: axon guidance; collagen catabolic process; extracellular matrix disassembly; receptor-mediated endocytosis; negative regulation of angiogenesis; extracellular matrix organization and biogenesis; transcription, DNA-dependent; angiogenesis Disease: Porencephaly 2; Hemorrhage, Intracerebral, Susceptibility To |
NCBI Summary: | This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008] |
UniProt Code: | P08572 |
NCBI GenInfo Identifier: | 116256354 |
NCBI Gene ID: | 1284 |
NCBI Accession: | NP_001837.2 |
UniProt Secondary Accession: | P08572,Q14052, Q548C3, Q5VZA9, Q66K23, |
UniProt Related Accession: | P08572 |
Molecular Weight: | 167,553 Da |
NCBI Full Name: | collagen alpha-2(IV) chain preproprotein |
NCBI Synonym Full Names: | collagen, type IV, alpha 2 |
NCBI Official Symbol: | COL4A2 |
NCBI Official Synonym Symbols: | ICH; POREN2 |
NCBI Protein Information: | collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; canstatin |
UniProt Protein Name: | Collagen alpha-2(IV) chain |
Protein Family: | Collagen |
UniProt Gene Name: | COL4A2 |
UniProt Entry Name: | CO4A2_HUMAN |
Antibodies | ELISA Kits |
Anti-COL4A2 Antibody (CAB7657) | Collagen IV alpha2 Colorimetric Cell-Based ELISA Kit |
COL4A2 Antibody (PACO06941) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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