CMA1 Antibody, HRP conjugated (PACO25819)
- SKU:
- PACO25819
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | CMA1 Antibody, HRP conjugated (PACO25819) |
抗体コード: | PACO25819 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Chymase protein (22-247AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. |
シノニム: | Chymase (EC 3.4.21.39) (Alpha-chymase) (Mast cell protease I), CMA1, CYH CYM |
UniProt Protein Function: | CMA1: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Belongs to the peptidase S1 family. Granzyme subfamily. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; EC 3.4.21.39; Protease Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: extracellular matrix; extracellular space; extracellular region; intracellular Molecular Function:serine-type peptidase activity; serine-type endopeptidase activity; peptide binding Biological Process: interleukin-1 beta biosynthetic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of angiogenesis; cellular protein metabolic process; regulation of inflammatory response; midbrain development; protein processing; proteolysis; angiotensin maturation |
NCBI Summary: | This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008] |
UniProt Code: | P23946 |
NCBI GenInfo Identifier: | 126825 |
NCBI Gene ID: | 1215 |
NCBI Accession: | P23946.1 |
UniProt Secondary Accession: | P23946,Q16018, Q3SY36, Q3SY37, Q9UDH5, B5BUM8, |
UniProt Related Accession: | P23946 |
Molecular Weight: | |
NCBI Full Name: | Chymase |
NCBI Synonym Full Names: | chymase 1, mast cell |
NCBI Official Symbol: | CMA1 |
NCBI Official Synonym Symbols: | CYH; MCT1; chymase |
NCBI Protein Information: | chymase; alpha-chymase; chymase, heart; chymase, mast cell; mast cell protease I; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I |
UniProt Protein Name: | Chymase |
UniProt Synonym Protein Names: | Alpha-chymase; Mast cell protease I |
Protein Family: | Chymase |
UniProt Gene Name: | CMA1 |
UniProt Entry Name: | CMA1_HUMAN |