CLDN11 Antibody, Biotin conjugated (PACO64210)
- SKU:
- PACO64210
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CLDN11 Antibody, Biotin conjugated (PACO64210) |
抗体コード: | PACO64210 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Claudin-11 protein (23-82AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
シノニム: | Claudin-11 (Oligodendrocyte-specific protein), CLDN11, OSP OTM |
UniProt Protein Function: | Claudin-11: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family. |
UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q26.2 Cellular Component: plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion |
NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010] |
UniProt Code: | O75508 |
NCBI GenInfo Identifier: | 6685300 |
NCBI Gene ID: | 5010 |
NCBI Accession: | O75508.2 |
UniProt Secondary Accession: | O75508,Q5U0P3, B2R7C1, D3DNQ5, |
UniProt Related Accession: | O75508 |
Molecular Weight: | 22kDa |
NCBI Full Name: | Claudin-11 |
NCBI Synonym Full Names: | claudin 11 |
NCBI Official Symbol: | CLDN11 |
NCBI Official Synonym Symbols: | OSP; OTM |
NCBI Protein Information: | claudin-11 |
UniProt Protein Name: | Claudin-11 |
UniProt Synonym Protein Names: | Oligodendrocyte-specific protein |
Protein Family: | Claudin |
UniProt Gene Name: | CLDN11 |