CHAT Antibody, HRP conjugated (PACO47351)
- SKU:
- PACO47351
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | CHAT Antibody, HRP conjugated (PACO47351) |
抗体コード: | PACO47351 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Choline O-acetyltransferase protein (354-592AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. |
シノニム: | Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6), CHAT |
UniProt Protein Function: | CHAT: an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described. |
UniProt Protein Details: | Protein type:EC 2.3.1.6; Lipid Metabolism - glycerophospholipid; Acetyltransferase Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: cell soma; mitochondrion; axon; cytoplasm; nucleus; cytosol Molecular Function:choline O-acetyltransferase activity Biological Process: rhythmic excitation; muscle development; neurotransmitter secretion; glycerophospholipid biosynthetic process; adult walking behavior; synaptic transmission; rhythmic behavior; phospholipid metabolic process; phosphatidylcholine biosynthetic process; dendrite development; neuromuscular synaptic transmission; establishment of synaptic specificity at neuromuscular junction; neurotransmitter biosynthetic process Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea |
NCBI Summary: | This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010] |
UniProt Code: | P28329 |
NCBI GenInfo Identifier: | 281185509 |
NCBI Gene ID: | 1103 |
NCBI Accession: | P28329.4 |
UniProt Secondary Accession: | P28329,Q16488, Q9BQ23, Q9BQ35, Q9BQE1, A2BDF4, A2BDF5 |
UniProt Related Accession: | P28329 |
Molecular Weight: | 748 |
NCBI Full Name: | Choline O-acetyltransferase |
NCBI Synonym Full Names: | choline O-acetyltransferase |
NCBI Official Symbol: | CHAT |
NCBI Official Synonym Symbols: | CMS1A; CMS1A2; CHOACTASE |
NCBI Protein Information: | choline O-acetyltransferase; choline acetylase; acetyl CoA:choline O-acetyltransferase |
UniProt Protein Name: | Choline O-acetyltransferase |
Protein Family: | (Z)-3-hexen-1-ol acetyltransferase |
UniProt Gene Name: | CHAT |
UniProt Entry Name: | CLAT_HUMAN |