CES2 Antibody (PACO05627)
- SKU:
- PACO05627
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CES2 Antibody (PACO05627) |
抗体コード: | PACO05627 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the Internal region of human CES2. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | CES2; ICE; Cocaine esterase; Carboxylesterase 2; CE-2; hCE-2; Methylumbelliferyl-acetate deacetylase 2 |
UniProt Protein Function: | CES2: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.1.1.84; EC 3.1.1.1; EC 3.1.1.56; Hydrolase Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: extracellular space; endoplasmic reticulum lumen; endoplasmic reticulum Molecular Function:methylumbelliferyl-acetate deacetylase activity Biological Process: catabolic process |
NCBI Summary: | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] |
UniProt Code: | O00748 |
NCBI GenInfo Identifier: | 46576349 |
NCBI Gene ID: | 8824 |
NCBI Accession: | O00748.1 |
UniProt Secondary Accession: | O00748,Q16859, Q5MAB8, Q7Z366, Q8IUP4, Q8TCP8, A8K367 |
UniProt Related Accession: | O00748 |
Molecular Weight: | 623 |
NCBI Full Name: | Cocaine esterase |
NCBI Synonym Full Names: | carboxylesterase 2 |
NCBI Official Symbol: | CES2 |
NCBI Official Synonym Symbols: | iCE; CE-2; PCE-2; CES2A1 |
NCBI Protein Information: | cocaine esterase; hCE-2; carboxylesterase 2 (intestine, liver); methylumbelliferyl-acetate deacetylase 2; intestinal carboxylesterase; liver carboxylesterase-2 |
UniProt Protein Name: | Cocaine esterase |
UniProt Synonym Protein Names: | Carboxylesterase 2 (EC:3.1.1.1); CE-2; hCE-2; Methylumbelliferyl-acetate deacetylase 2 (EC:3.1.1.56) |
Protein Family: | Liver carboxylesterase |
UniProt Gene Name: | CES2 |
UniProt Entry Name: | EST2_HUMAN |