CELSR2 Antibody (PACO19033)
- SKU:
- PACO19033
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CELSR2 Antibody (PACO19033) |
抗体コード: | PACO19033 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human CELSR2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19033(CELSR2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19033(CELSR2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. |
シノニム: | cadherin, EGF LAG seven-pass G-type receptor 2 |
UniProt Protein Function: | CELSR2: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. |
UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; Cell development/differentiation; Membrane protein, integral; GPCR, family 2 Chromosomal Location of Human Ortholog: 1p21 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; calcium ion binding Biological Process: G-protein coupled receptor protein signaling pathway; cerebrospinal fluid secretion; regulation of protein localization; Wnt receptor signaling pathway; regulation of cell-cell adhesion; regulation of transcription, DNA-dependent; neural plate anterioposterior pattern formation; ventricular system development; dendrite morphogenesis; neuron migration; cilium biogenesis; homophilic cell adhesion |
NCBI Summary: | The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HCU4 |
NCBI GenInfo Identifier: | 22095550 |
NCBI Gene ID: | 1952 |
NCBI Accession: | Q9HCU4.1 |
UniProt Secondary Accession: | Q9HCU4,Q5T2Y7, Q92566, |
UniProt Related Accession: | Q9HCU4 |
Molecular Weight: | 317,453 Da |
NCBI Full Name: | Cadherin EGF LAG seven-pass G-type receptor 2 |
NCBI Synonym Full Names: | cadherin, EGF LAG seven-pass G-type receptor 2 |
NCBI Official Symbol: | CELSR2 |
NCBI Official Synonym Symbols: | EGFL2; MEGF3; CDHF10; Flamingo1 |
NCBI Protein Information: | cadherin EGF LAG seven-pass G-type receptor 2; EGF-like protein 2; flamingo homolog 3; cadherin family member 10; EGF-like-domain, multiple 2; epidermal growth factor-like 2; multiple EGF-like domains protein 3; epidermal growth factor-like protein 2; multiple epidermal growth factor-like domains 3; multiple epidermal growth factor-like domains protein 3; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) |
UniProt Protein Name: | Cadherin EGF LAG seven-pass G-type receptor 2 |
UniProt Synonym Protein Names: | Cadherin family member 10; Epidermal growth factor-like protein 2; EGF-like protein 2; Flamingo homolog 3; Multiple epidermal growth factor-like domains protein 3; Multiple EGF-like domains protein 3 |
Protein Family: | Cadherin EGF LAG seven-pass G-type receptor |
UniProt Gene Name: | CELSR2 |
UniProt Entry Name: | CELR2_HUMAN |