CDK2AP1 Antibody, FITC conjugated (PACO25674)
- SKU:
- PACO25674
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | CDK2AP1 Antibody, FITC conjugated (PACO25674) |
抗体コード: | PACO25674 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Cyclin-dependent kinase 2-associated protein 1 protein (1-115AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | specific inhibitor of the cell-cycle kinase CDK2 |
シノニム: | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor), CDK2AP1, CDKAP1 DOC1 |
UniProt Protein Function: | CDK2AP1: specific inhibitor of the cell-cycle kinase CDK2. Belongs to the CDK2AP family. |
UniProt Protein Details: | Protein type:DNA replication; Tumor suppressor; Cell cycle regulation Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: perinuclear region of cytoplasm; nucleus Biological Process: positive regulation of protein amino acid phosphorylation; DNA-dependent DNA replication; cell cycle |
NCBI Summary: | The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
UniProt Code: | O14519 |
NCBI GenInfo Identifier: | 6014988 |
NCBI Gene ID: | 8099 |
NCBI Accession: | O14519.1 |
UniProt Secondary Accession: | O14519,F5GYA4, |
UniProt Related Accession: | O14519 |
Molecular Weight: | 115 |
NCBI Full Name: | Cyclin-dependent kinase 2-associated protein 1 |
NCBI Synonym Full Names: | cyclin-dependent kinase 2 associated protein 1 |
NCBI Official Symbol: | CDK2AP1 |
NCBI Official Synonym Symbols: | DOC1; ST19; DORC1; doc-1; p12DOC-1 |
NCBI Protein Information: | cyclin-dependent kinase 2-associated protein 1; Deleted in oral cancer-1; deleted in oral cancer 1; CDK2-associated protein 1; putative oral cancer suppressor |
UniProt Protein Name: | Cyclin-dependent kinase 2-associated protein 1 |
UniProt Synonym Protein Names: | Deleted in oral cancer 1; DOC-1; Putative oral cancer suppressor |
Protein Family: | Cyclin-dependent kinase 2-associated protein |
UniProt Gene Name: | CDK2AP1 |
UniProt Entry Name: | CDKA1_HUMAN |