UniProt Protein Function: | CDK13: a CMGC protein kinase of the CDK family. It has been reported to interact with L-type cyclins. Overexpression of CDC2L5 constructs disturbs constitutive splicing and switches alternative splice site selection in vivo suggesting that it may regulate alternative splicing. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing Chromosomal Location of Human Ortholog: 7p14.1 Cellular Component: chromosome; cytosol; extracellular region; extracellular space; Golgi apparatus; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm; transcription elongation factor complex b Molecular Function:cyclin binding; cyclin-dependent protein kinase activity; protein binding; protein kinase activity; RNA binding; RNA polymerase subunit kinase activity; transcription factor binding Biological Process: alternative nuclear mRNA splicing, via spliceosome; hemopoiesis; multicellular organismal development; neutrophil degranulation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of mitosis; RNA elongation from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009] |
UniProt Code: | Q14004 |
NCBI GenInfo Identifier: | 66774048 |
NCBI Gene ID: | 8621 |
NCBI Accession: | Q14004.2 |
UniProt Secondary Accession: | Q14004,Q53G78, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0 Q9H4A1, Q9UDR4, |
UniProt Related Accession: | Q14004 |
Molecular Weight: | Observed MW: 210kDaCalculated MW: 158kDa/164kDa |
NCBI Full Name: | Cyclin-dependent kinase 13 |
NCBI Synonym Full Names: | cyclin dependent kinase 13 |
NCBI Official Symbol: | CDK13 |
NCBI Official Synonym Symbols: | CHED; CDC2L; CDC2L5; hCDK13; CHDFIDD |
NCBI Protein Information: | cyclin-dependent kinase 13 |
UniProt Protein Name: | Cyclin-dependent kinase 13 |
UniProt Synonym Protein Names: | CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; hCDK13; Cholinesterase-related cell division controller |
Protein Family: | Cyclin-dependent kinase |
UniProt Gene Name: | CDK13 |