CDC20 Antibody (PACO06334)
- SKU:
- PACO06334
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | CDC20 Antibody (PACO06334) |
抗体コード: | PACO06334 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from the Internal region of human Cdc20. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of NIH-3T3 cells using Cdc20 Polyclonal Antibody. | |
Western Blot analysis of 3T3 cells using Cdc20 Polyclonal Antibody. |
シノニム: | CDC20; Cell division cycle protein 20 homolog; p55CDC |
UniProt Protein Function: | CDC20: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2. Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2. Belongs to the WD repeat CDC20/Fizzy family. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: anaphase-promoting complex; cytoplasm; cytosol; nucleoplasm; nucleus; spindle Molecular Function:enzyme binding; protein binding; protein C-terminus binding Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of synaptic plasticity; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; sister chromatid cohesion |
NCBI Summary: | CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12834 |
NCBI GenInfo Identifier: | 37537762 |
NCBI Gene ID: | 991 |
NCBI Accession: | Q12834.2 |
UniProt Secondary Accession: | Q12834,Q5JUY4, Q9BW56, Q9UQI9, B2R6Z6, D3DPJ1, |
UniProt Related Accession: | Q12834 |
Molecular Weight: | 54,723 Da |
NCBI Full Name: | Cell division cycle protein 20 homolog |
NCBI Synonym Full Names: | cell division cycle 20 |
NCBI Official Symbol: | CDC20 |
NCBI Official Synonym Symbols: | CDC20A; p55CDC; bA276H19.3 |
NCBI Protein Information: | cell division cycle protein 20 homolog |
UniProt Protein Name: | Cell division cycle protein 20 homolog |
UniProt Synonym Protein Names: | p55CDC |
Protein Family: | Cell division cycle protein |
UniProt Gene Name: | CDC20 |
UniProt Entry Name: | CDC20_HUMAN |