CD3E Antibody (PACO51402)
- SKU:
- PACO51402
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | CD3E Antibody (PACO51402) |
抗体コード: | PACO51402 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain protein (23-126AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO51402 at dilution of 1:100. | |
Immunofluorescent analysis of A549 cells using PACO51402 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO51402 at dilution of 1:100. |
バックグラウンド: | The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses. |
シノニム: | T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e), CD3E, T3E |
UniProt Protein Function: | CD3E: a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q23 Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; immunological synapse; alpha-beta T cell receptor complex; intercellular junction; external side of plasma membrane Molecular Function:protein binding; transmembrane receptor activity; receptor signaling complex scaffold activity; protein heterodimerization activity; receptor signaling protein activity; T cell receptor binding; SH3 domain binding; protein kinase binding Biological Process: regulation of immune response; T cell activation; positive regulation of interleukin-2 biosynthetic process; signal complex assembly; positive regulation of calcium-mediated signaling; negative thymic T cell selection; T cell receptor signaling pathway; positive regulation of interleukin-4 production; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; negative regulation of smoothened signaling pathway; T cell costimulation; protein complex assembly; positive regulation of alpha-beta T cell proliferation; positive regulation of T cell proliferation; positive regulation of T cell anergy; transmembrane receptor protein tyrosine kinase signaling pathway; response to nutrient Disease: Immunodeficiency 18 |
NCBI Summary: | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008] |
UniProt Code: | P07766 |
NCBI GenInfo Identifier: | 1345708 |
NCBI Gene ID: | 916 |
NCBI Accession: | P07766.2 |
UniProt Related Accession: | P07766 |
Molecular Weight: | |
NCBI Full Name: | T-cell surface glycoprotein CD3 epsilon chain |
NCBI Synonym Full Names: | CD3e molecule |
NCBI Official Symbol: | CD3E |
NCBI Official Synonym Symbols: | T3E; TCRE; IMD18 |
NCBI Protein Information: | T-cell surface glycoprotein CD3 epsilon chain |
UniProt Protein Name: | T-cell surface glycoprotein CD3 epsilon chain |
UniProt Synonym Protein Names: | T-cell surface antigen T3/Leu-4 epsilon chain; CD_antigen: CD3e |
UniProt Gene Name: | CD3E |
UniProt Entry Name: | CD3E_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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