CD247 Antibody (PACO50150)
- SKU:
- PACO50150
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CD247 Antibody (PACO50150) |
抗体コード: | PACO50150 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF, IP |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000, |
反応性: | Human |
免疫原: | Recombinant Human T-cell surface glycoprotein CD3 zeta chain protein (88-153AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Jurkat whole cell lysate. All lanes: CD247 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 19 kDa. Observed band size: 19 kDa.. | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO50150 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO50150 at dilution of 1:100. |
バックグラウンド: | Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. |
シノニム: | T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247), CD247, CD3Z T3Z TCRZ |
UniProt Protein Function: | CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex Molecular Function:identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity Biological Process: regulation of immune response; viral reproduction; T cell costimulation; innate immune response; T cell receptor signaling pathway; regulation of defense response to virus by virus Disease: Immunodeficiency 25 |
NCBI Summary: | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P20963 |
NCBI GenInfo Identifier: | 4557431 |
NCBI Gene ID: | 919 |
NCBI Accession: | NP_000725.1 |
UniProt Secondary Accession: | P20963,Q5VX13, Q8TAX4, B1AK49, |
UniProt Related Accession: | P20963,A46461 |
Molecular Weight: | 18,696 Da |
NCBI Full Name: | T-cell surface glycoprotein CD3 zeta chain isoform 2 |
NCBI Synonym Full Names: | CD247 molecule |
NCBI Official Symbol: | CD247 |
NCBI Official Synonym Symbols: | T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA |
NCBI Protein Information: | T-cell surface glycoprotein CD3 zeta chain; CD3zeta chain; TCR zeta chain; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3 |
UniProt Protein Name: | T-cell surface glycoprotein CD3 zeta chain |
UniProt Synonym Protein Names: | T-cell receptor T3 zeta chain |
UniProt Gene Name: | CD247 |
UniProt Entry Name: | CD3Z_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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