CD180 Antibody (PACO45338)
- SKU:
- PACO45338
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CD180 Antibody (PACO45338) |
抗体コード: | PACO45338 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human CD180 antigen protein (24-220AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CD180 antibody at 3.95µg/ml. Lane 1: A549 whole cell lysate. Lane 2: A431 whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 74 kDa. Observed band size: 74 kDa.. | |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO45338 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45338 at dilution of 1:100. |
バックグラウンド: | May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). |
シノニム: | CD180 antigen (Lymphocyte antigen 64) (Radioprotective 105 kDa protein) (CD antigen CD180), CD180, LY64 RP105 |
UniProt Protein Function: | CD180: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. Belongs to the Toll-like receptor family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 5q12.3 Cellular Component: integral to plasma membrane Molecular Function:receptor activity Biological Process: inflammatory response; positive regulation of lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway |
NCBI Summary: | CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99467 |
NCBI GenInfo Identifier: | 296434437 |
NCBI Gene ID: | 4064 |
NCBI Accession: | Q99467.2 |
UniProt Secondary Accession: | Q99467,Q32MM5, B2R7Z7, |
UniProt Related Accession: | Q99467 |
Molecular Weight: | 74kDa |
NCBI Full Name: | CD180 antigen |
NCBI Synonym Full Names: | CD180 molecule |
NCBI Official Symbol: | CD180 |
NCBI Official Synonym Symbols: | LY64; Ly78; RP105 |
NCBI Protein Information: | CD180 antigen |
UniProt Protein Name: | CD180 antigen |
UniProt Synonym Protein Names: | Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD_antigen: CD180 |
Protein Family: | CD180 antigen |
UniProt Gene Name: | CD180 |