CBX1 Antibody (PACO17659)
- SKU:
- PACO17659
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CBX1 Antibody (PACO17659) |
抗体コード: | PACO17659 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human CBX1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO17659(CBX1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. |
シノニム: | chromobox homolog 1 |
UniProt Protein Function: | CBX1: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. Expressed in all adult and embryonic tissues. |
UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: nucleoplasm; centric heterochromatin; male pronucleus; female pronucleus; spindle; nuclear heterochromatin; chromatin; chromosome, pericentric region; chromocenter Molecular Function:protein binding; protein homodimerization activity; enzyme binding; chromatin binding Biological Process: negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008] |
UniProt Code: | P83916 |
NCBI GenInfo Identifier: | 48428808 |
NCBI Gene ID: | 5077 |
NCBI Accession: | P83916.1 |
UniProt Related Accession: | P23760 |
Molecular Weight: | |
NCBI Full Name: | Chromobox protein homolog 1 |
NCBI Synonym Full Names: | paired box 3 |
NCBI Official Symbol: | PAX3 |
NCBI Official Synonym Symbols: | WS1; WS3; CDHS; HUP2 |
NCBI Protein Information: | paired box protein Pax-3 |
UniProt Protein Name: | Chromobox protein homolog 1 |
UniProt Synonym Protein Names: | HP1Hsbeta; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta |
Protein Family: | Chromobox protein |
UniProt Gene Name: | CBX1 |
UniProt Entry Name: | CBX1_HUMAN |