CBLC Antibody (PACO43702)
- SKU:
- PACO43702
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CBLC Antibody (PACO43702) |
抗体コード: | PACO43702 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CBLC antibody at 14µg/ml. Lane 1: A549 whole cell lysate. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 53, 48 kDa. Observed band size: 53 kDa. | |
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO43702 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43702 at dilution of 1:100. |
バックグラウンド: | Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. |
シノニム: | E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C), CBLC, CBL3 RNF57 |
UniProt Protein Function: | Cbl-c: Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: nucleus Molecular Function:signal transducer activity; phosphotyrosine binding; zinc ion binding; calcium ion binding; SH3 domain binding; ligase activity; epidermal growth factor receptor binding Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination |
NCBI Summary: | This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q9ULV8 |
NCBI GenInfo Identifier: | 125987803 |
NCBI Gene ID: | 23624 |
NCBI Accession: | Q9ULV8.3 |
UniProt Related Accession: | Q9ULV8 |
Molecular Weight: | ~ 52kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase CBL-C |
NCBI Synonym Full Names: | Cbl proto-oncogene C |
NCBI Official Symbol: | CBLC |
NCBI Official Synonym Symbols: | CBL-3; RNF57; CBL-SL |
NCBI Protein Information: | E3 ubiquitin-protein ligase CBL-C |
UniProt Protein Name: | E3 ubiquitin-protein ligase CBL-C |
UniProt Synonym Protein Names: | RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | CBLC |
UniProt Entry Name: | CBLC_HUMAN |