CADM1 Antibody (PACO43134)
- SKU:
- PACO43134
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | CADM1 Antibody (PACO43134) |
抗体コード: | PACO43134 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Cell adhesion molecule 1 protein (45-344AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43134 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO43134 at dilution of 1:100. |
バックグラウンド: | Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-γ (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. |
シノニム: | Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1), CADM1, IGSF4 IGSF4A NECL2 SYNCAM TSLC1 |
UniProt Protein Function: | CADM1: a single-pass type I membrane protein that ediates homophilic cell-cell adhesion, and heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; Cell adhesion; Membrane protein, integral; Tumor suppressor; Vesicle Chromosomal Location of Human Ortholog: 11q23.2 Cellular Component: basolateral plasma membrane; cell-cell adherens junction; integral to plasma membrane; intercellular junction; plasma membrane Molecular Function:cell adhesion molecule binding; PDZ domain binding; protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: activated T cell proliferation; cell recognition; detection of stimulus; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of cytokine secretion; positive regulation of natural killer cell mediated cytotoxicity; susceptibility to natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity |
UniProt Code: | Q9BY67 |
NCBI GenInfo Identifier: | 150438862 |
NCBI Gene ID: | 23705 |
NCBI Accession: | Q9BY67.2 |
UniProt Secondary Accession: | Q9BY67,Q86WB8, Q8N2F4, A4FVB5, F5H0J4, H0YGA7, H1ZZV9 H1ZZW1, H1ZZW2, X5D2C8, |
UniProt Related Accession: | Q9BY67 |
Molecular Weight: | 45,624 Da |
NCBI Full Name: | Cell adhesion molecule 1 |
NCBI Synonym Full Names: | cell adhesion molecule 1 |
NCBI Official Symbol: | CADM1 |
NCBI Official Synonym Symbols: | BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1 |
NCBI Protein Information: | cell adhesion molecule 1 |
UniProt Protein Name: | Cell adhesion molecule 1 |
UniProt Synonym Protein Names: | Immunoglobulin superfamily member 4; IgSF4; Nectin-like protein 2; NECL-2; Spermatogenic immunoglobulin superfamily; SgIgSF; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor in lung cancer 1; TSLC-1 |
Protein Family: | Cell adhesion molecule |
UniProt Gene Name: | CADM1 |
UniProt Entry Name: | CADM1_HUMAN |