UniProt Protein Function: | BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family. |
UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis; Membrane protein, integral; Nuclear envelope; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 8p21 Cellular Component: endoplasmic reticulum; intrinsic to membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope Molecular Function:identical protein binding; lamin binding; protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: defense response to virus; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of macroautophagy; regulation of apoptosis |
NCBI Summary: | This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015] |
UniProt Code: | O60238 |
NCBI GenInfo Identifier: | 6093509 |
NCBI Gene ID: | 665 |
NCBI Accession: | O60238.1 |
UniProt Secondary Accession: | O60238,Q5JW63, Q8NF87, B0AZS9, |
UniProt Related Accession: | O60238 |
Molecular Weight: | 19,559 Da |
NCBI Full Name: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
NCBI Synonym Full Names: | BCL2 interacting protein 3 like |
NCBI Official Symbol: | BNIP3L |
NCBI Official Synonym Symbols: | NIX; BNIP3a |
NCBI Protein Information: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
UniProt Protein Name: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
UniProt Synonym Protein Names: | Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X; NIP3L |
Protein Family: | BCL2/adenovirus E1B 19 kDa protein-interacting protein |
UniProt Gene Name: | BNIP3L |
UniProt Entry Name: | BNI3L_HUMAN |