UniProt Protein Function: | BID: a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found. |
UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis Chromosomal Location of Human Ortholog: 22q11.1 Cellular Component: cytosol; membrane; mitochondrial outer membrane; mitochondrion Molecular Function:death receptor binding; protein binding Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction; induction of apoptosis via death domain receptors; neuron apoptosis; positive regulation of apoptosis; positive regulation of protein homooligomerization; positive regulation of protein oligomerization; regulation of apoptosis; release of cytochrome c from mitochondria |
NCBI Summary: | This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] |
UniProt Code: | P55957 |
NCBI GenInfo Identifier: | 2493285 |
NCBI Gene ID: | 637 |
NCBI Accession: | P55957.1 |
UniProt Secondary Accession: | P55957,Q549M7, Q71T04, Q7Z4M9, Q8IY86, |
UniProt Related Accession: | P55957 |
Molecular Weight: | 11,263 Da |
NCBI Full Name: | BH3-interacting domain death agonist |
NCBI Synonym Full Names: | BH3 interacting domain death agonist |
NCBI Official Symbol: | BID |
NCBI Official Synonym Symbols: | FP497 |
NCBI Protein Information: | BH3-interacting domain death agonist |
UniProt Protein Name: | BH3-interacting domain death agonist |
UniProt Synonym Protein Names: | p22 BID; BID |
Protein Family: | BH3-interacting domain death agonist |
UniProt Gene Name: | BID |
UniProt Entry Name: | BID_HUMAN |