BCL2L10 Antibody (PACO07994)
- SKU:
- PACO07994
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | BCL2L10 Antibody (PACO07994) |
抗体コード: | PACO07994 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human BCL2L10 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | BCL2-like 10 (apoptosis facilitator);BCL2L10;BCL-B;Boo;Diva;MGC129810;MGC129811 ; |
UniProt Protein Function: | BCL2L10: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 15q21 Cellular Component: mitochondrial outer membrane; nuclear membrane; membrane; mitochondrion; integral to membrane; cytosol Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis |
NCBI Summary: | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HD36 |
NCBI GenInfo Identifier: | 13898394 |
NCBI Gene ID: | 10017 |
NCBI Accession: | AAK48715.1 |
UniProt Secondary Accession: | Q9HD36,Q3SX80, Q52LQ9, Q8TCS9, |
UniProt Related Accession: | Q9HD36 |
Molecular Weight: | 23 kDa |
NCBI Full Name: | BCLB |
NCBI Synonym Full Names: | BCL2-like 10 (apoptosis facilitator) |
NCBI Official Symbol: | BCL2L10 |
NCBI Official Synonym Symbols: | Boo; Diva; BCL-B; bcl2-L-10 |
NCBI Protein Information: | bcl-2-like protein 10 |
UniProt Protein Name: | Bcl-2-like protein 10 |
UniProt Synonym Protein Names: | Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B |
UniProt Gene Name: | BCL2L10 |
UniProt Entry Name: | B2L10_HUMAN |