BCAT1 Antibody (PACO15853)
- SKU:
- PACO15853
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | BCAT1 Antibody (PACO15853) |
抗体コード: | PACO15853 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human BCAT1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15853(BCAT1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes the cytosolic form of the enzyme branched-chain amino acid, transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acid, to branched-chain L-amino acid, essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid, transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. |
シノニム: | branched chain amino-acid, transaminase 1, cytosolic |
UniProt Protein Function: | BCAT1: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.6.1.42; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Transferase Chromosomal Location of Human Ortholog: 12p12.1 Cellular Component: mitochondrion; cytosol Molecular Function:identical protein binding; branched-chain-amino-acid transaminase activity Biological Process: cell proliferation; branched chain family amino acid catabolic process; branched chain family amino acid biosynthetic process; G1/S transition of mitotic cell cycle |
NCBI Summary: | This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010] |
UniProt Code: | P54687 |
NCBI GenInfo Identifier: | 215274162 |
NCBI Gene ID: | 586 |
NCBI Accession: | P54687.3 |
UniProt Secondary Accession: | P54687,Q68DQ7, Q96MY9, B3KY27, B7Z2M5, B7Z5L0, F5H5E4 |
UniProt Related Accession: | P54687 |
Molecular Weight: | 386 |
NCBI Full Name: | Branched-chain-amino-acid aminotransferase, cytosolic |
NCBI Synonym Full Names: | branched chain amino-acid transaminase 1, cytosolic |
NCBI Official Symbol: | BCAT1 |
NCBI Official Synonym Symbols: | BCT1; PP18; BCATC; ECA39; MECA39; PNAS121 |
NCBI Protein Information: | branched-chain-amino-acid aminotransferase, cytosolic; placental protein 18; branched chain aminotransferase 1, cytosolic |
UniProt Protein Name: | Branched-chain-amino-acid aminotransferase, cytosolic |
UniProt Synonym Protein Names: | Protein ECA39 |
Protein Family: | Branched-chain-amino-acid aminotransferase |
UniProt Gene Name: | BCAT1 |
UniProt Entry Name: | BCAT1_HUMAN |