BCAR1 Antibody, Biotin conjugated (PACO53609)
- SKU:
- PACO53609
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | BCAR1 Antibody, Biotin conjugated (PACO53609) |
抗体コード: | PACO53609 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Breast cancer anti-estrogen resistance protein 1 protein (68-218AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. |
シノニム: | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas), BCAR1, CAS CASS1 CRKAS |
UniProt Protein Function: | P130Cas: a docking protein containing multiple protein-protein interaction domains. Plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. The amino-terminal SH3 domain regulates its interaction with focal adhesion kinase (FAK) and the FAK-related kinase PYK2 and also with tyrosine phosphatases PTP-1B and PTP-PEST. Overexpression confers antiestrogen resistance on breast cancer cells. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q23.1 Cellular Component: ruffle; focal adhesion; lamellipodium; cytoplasm; nucleolus; plasma membrane; cytosol; actin cytoskeleton Molecular Function:signal transducer activity; protein binding; SH3 domain binding; protein kinase binding Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; antigen receptor-mediated signaling pathway; platelet activation; cell migration; nerve growth factor receptor signaling pathway; actin filament organization; hepatocyte growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; T cell receptor signaling pathway; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; cell proliferation; B cell receptor signaling pathway; cell division; insulin receptor signaling pathway; regulation of cell growth; cell adhesion; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of cell migration |
NCBI Summary: | BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009] |
UniProt Code: | P56945 |
NCBI GenInfo Identifier: | 288558806 |
NCBI Gene ID: | 9564 |
NCBI Accession: | P56945.2 |
UniProt Secondary Accession: | P56945,B3KWD7, B4DEV4, B4DGB5, B4DIW5, B7Z7X7, E9PCL5 E9PCV2, F5GXA2, F5GXV6, F5H7Z0, F8WA69, |
UniProt Related Accession: | P56945 |
Molecular Weight: | 870 |
NCBI Full Name: | Breast cancer anti-estrogen resistance protein 1 |
NCBI Synonym Full Names: | breast cancer anti-estrogen resistance 1 |
NCBI Official Symbol: | BCAR1 |
NCBI Official Synonym Symbols: | CAS; CAS1; CASS1; CRKAS; P130Cas |
NCBI Protein Information: | breast cancer anti-estrogen resistance protein 1; Crk-associated substrate p130Cas; Cas scaffolding protein family member 1 |
UniProt Protein Name: | Breast cancer anti-estrogen resistance protein 1 |
UniProt Synonym Protein Names: | CRK-associated substrate; Cas scaffolding protein family member 1; p130cas |
Protein Family: | Breast cancer anti-estrogen resistance protein |
UniProt Gene Name: | BCAR1 |
UniProt Entry Name: | BCAR1_HUMAN |