BATF Antibody (PACO35546)
- SKU:
- PACO35546
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | BATF Antibody (PACO35546) |
抗体コード: | PACO35546 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: BATF antibody at 6µg/ml + NIH/3T3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 15 kDa. Observed band size: 15 kDa. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO35546 at dilution of 1:100. |
バックグラウンド: | AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). |
シノニム: | Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF) (SF-HT-activated gene 2 protein) (SFA-2), BATF |
UniProt Protein Function: | BATF: a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13- acetate response element (TRE) and weaker at the cAMP responsive region (CRE), but are transcriptionally inert. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: cytokine production; defense response to protozoan; DNA damage response, signal transduction by p53 class mediator; isotype switching; lymphoid progenitor cell differentiation; myeloid dendritic cell differentiation; response to DNA damage stimulus; T-helper 2 cell differentiation |
NCBI Summary: | The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16520 |
NCBI GenInfo Identifier: | 32171340 |
NCBI Gene ID: | 10538 |
NCBI Accession: | Q16520.1 |
UniProt Related Accession: | Q16520 |
Molecular Weight: | 14,120 Da |
NCBI Full Name: | Basic leucine zipper transcriptional factor ATF-like |
NCBI Synonym Full Names: | basic leucine zipper ATF-like transcription factor |
NCBI Official Symbol: | BATF |
NCBI Official Synonym Symbols: | SFA2; B-ATF; BATF1; SFA-2 |
NCBI Protein Information: | basic leucine zipper transcriptional factor ATF-like |
UniProt Protein Name: | Basic leucine zipper transcriptional factor ATF-like |
UniProt Synonym Protein Names: | B-cell-activating transcription factor; B-ATF; SF-HT-activated gene 2 protein; SFA-2 |
Protein Family: | Basic leucine zipper transcriptional factor |
UniProt Gene Name: | BATF |
UniProt Entry Name: | BATF_HUMAN |