BAIAP2L1 Antibody (PACO00985)
- SKU:
- PACO00985
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | BAIAP2L1 Antibody |
抗体コード: | PACO00985 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human IRTKS. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | BAIAP2L1; IRTKS; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate |
UniProt Protein Function: | IRTKS: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; actin cytoskeleton Molecular Function:protein binding; actin binding Biological Process: regulation of insulin receptor signaling pathway; response to bacterium; positive regulation of actin filament polymerization; plasma membrane organization and biogenesis |
NCBI Summary: | This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q9UHR4 |
NCBI GenInfo Identifier: | 32171238 |
NCBI Gene ID: | 55971 |
NCBI Accession: | NP_061330.2 |
UniProt Secondary Accession: | Q9UHR4,Q75L21, Q75L22, Q96CV4, Q9H5F5, Q9Y2M8, A4D268 |
UniProt Related Accession: | Q9UHR4 |
Molecular Weight: | 57kd |
NCBI Full Name: | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 |
NCBI Synonym Full Names: | BAI1-associated protein 2-like 1 |
NCBI Official Symbol: | BAIAP2L1 |
NCBI Official Synonym Symbols: | IRTKS |
NCBI Protein Information: | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 |
UniProt Protein Name: | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 |
UniProt Synonym Protein Names: | Insulin receptor tyrosine kinase substrate |
UniProt Gene Name: | BAIAP2L1 |
UniProt Entry Name: | BI2L1_HUMAN |