UniProt Protein Function: | axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 17q24.1 Cellular Component: nucleoplasm; microtubule cytoskeleton; Golgi apparatus; centrosome; cytoplasmic microtubule; cytoplasm; cytoplasmic membrane-bound vesicle; postsynaptic density; plasma membrane; cell cortex; cytosol; nucleus; beta-catenin destruction complex Molecular Function:protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity Biological Process: odontogenesis; negative regulation of cell proliferation; cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; dorsal/ventral axis specification; negative regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity Disease: Oligodontia-colorectal Cancer Syndrome |
NCBI Summary: | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y2T1 |
NCBI GenInfo Identifier: | 12643949 |
NCBI Gene ID: | 8313 |
NCBI Accession: | Q9Y2T1.1 |
UniProt Secondary Accession: | Q9Y2T1,Q3MJ88, Q9H3M6, Q9UH84, |
UniProt Related Accession: | Q9Y2T1 |
Molecular Weight: | 843 |
NCBI Full Name: | Axin-2 |
NCBI Synonym Full Names: | axin 2 |
NCBI Official Symbol: | AXIN2 |
NCBI Official Synonym Symbols: | AXIL; ODCRCS |
NCBI Protein Information: | axin-2; conductin; axin-like protein; axis inhibition protein 2 |
UniProt Protein Name: | Axin-2 |
UniProt Synonym Protein Names: | Axin-like protein; Axil; Axis inhibition protein 2; Conductin |
Protein Family: | Axin |
UniProt Gene Name: | AXIN2 |
UniProt Entry Name: | AXIN2_HUMAN |