AURKC Antibody (PACO19180)
- SKU:
- PACO19180
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | AURKC Antibody (PACO19180) |
抗体コード: | PACO19180 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human AURKC |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Mouse testis tissue, hela cells, human liver cancer tissue, A375 cells, 293T cells, Primary antibody: PACO19180(AURKC Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19180(AURKC Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. |
シノニム: | aurora kinase C |
UniProt Protein Function: | AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Other group; AUR family Chromosomal Location of Human Ortholog: 19q13.43 Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome Molecular Function:histone serine kinase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity Biological Process: attachment of spindle microtubules to kinetochore; histone modification; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis Disease: Spermatogenic Failure 5 |
NCBI Summary: | This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UQB9 |
NCBI GenInfo Identifier: | 27805738 |
NCBI Gene ID: | 6795 |
NCBI Accession: | Q9UQB9.1 |
UniProt Secondary Accession: | Q9UQB9,O60681, O75442, Q6AZY8, Q6DLZ0, Q9UPK5, |
UniProt Related Accession: | Q9UQB9 |
Molecular Weight: | 33,672 Da |
NCBI Full Name: | Aurora kinase C |
NCBI Synonym Full Names: | aurora kinase C |
NCBI Official Symbol: | AURKC |
NCBI Official Synonym Symbols: | AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C |
NCBI Protein Information: | aurora kinase C |
UniProt Protein Name: | Aurora kinase C |
UniProt Synonym Protein Names: | Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C |
Protein Family: | Aurora kinase |
UniProt Gene Name: | AURKC |
UniProt Entry Name: | AURKC_HUMAN |