ATP1B1 Antibody (PACO03209)
- SKU:
- PACO03209
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ATP1B1 Antibody |
抗体コード: | PACO03209 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | WB |
推奨される希釈: | |
反応性: | Mouse, Rat, Human |
免疫原: | synthetic Peptide |
憲法: | Liquid |
ストレージバッファ: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | Sodium/potassium-transporting ATPase subunit beta-1 |
UniProt Protein Function: | ATP1B1: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24 Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; intracellular; membrane; myelin sheath; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex Molecular Function:ATP binding; ATPase activator activity; ATPase activity; ATPase binding; drug binding; potassium ion binding; protein binding; protein C-terminus binding; sodium ion binding; sodium:potassium-exchanging ATPase activity Biological Process: ATP metabolic process; blood coagulation; cardiac muscle contraction; cell adhesion; cellular calcium ion homeostasis; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; leukocyte migration; positive regulation of ATPase activity; positive regulation of defense response to virus by host; potassium ion import; protein stabilization; regulation of gene expression; response to hypoxia; transmembrane transport Disease: Hypertension, Essential |
NCBI Summary: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010] |
UniProt Code: | P05026 |
NCBI GenInfo Identifier: | 114392 |
NCBI Gene ID: | 481 |
NCBI Accession: | P05026.1 |
UniProt Secondary Accession: | P05026,Q5TGZ3, |
UniProt Related Accession: | P05026 |
Molecular Weight: | 34,893 Da |
NCBI Full Name: | Sodium/potassium-transporting ATPase subunit beta-1 |
NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit beta 1 |
NCBI Official Symbol: | ATP1B1 |
NCBI Official Synonym Symbols: | ATP1B |
NCBI Protein Information: | sodium/potassium-transporting ATPase subunit beta-1 |
UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit beta-1 |
UniProt Synonym Protein Names: | Sodium/potassium-dependent ATPase subunit beta-1 |
UniProt Gene Name: | ATP1B1 |
UniProt Entry Name: | AT1B1_HUMAN |