UniProt Protein Function: | Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE). |
NCBI Summary: | This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013] |
UniProt Code: | Q9HBZ2 |
NCBI GenInfo Identifier: | 125987793 |
NCBI Gene ID: | 9915 |
NCBI Accession: | Q9HBZ2.2 |
UniProt Secondary Accession: | Q9HBZ2,O15024, Q8IYC2, B4DIS7, |
UniProt Related Accession: | Q9HBZ2 |
Molecular Weight: | 77,612 Da |
NCBI Full Name: | Aryl hydrocarbon receptor nuclear translocator 2 |
NCBI Synonym Full Names: | aryl hydrocarbon receptor nuclear translocator 2 |
NCBI Official Symbol: | ARNT2 |
NCBI Official Synonym Symbols: | WEDAS; bHLHe1 |
NCBI Protein Information: | aryl hydrocarbon receptor nuclear translocator 2 |
UniProt Protein Name: | Aryl hydrocarbon receptor nuclear translocator 2 |
UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 1; bHLHe1 |
Protein Family: | Aryl hydrocarbon receptor nuclear translocator |
UniProt Gene Name: | ARNT2 |