ARL3 Antibody (PACO19322)
- SKU:
- PACO19322
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARL3 Antibody (PACO19322) |
抗体コード: | PACO19322 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human ARL3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, 231 cells, A375 cells, Primary antibody: PACO19322(ARL3 Antibody) at dilution 1/433, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
バックグラウンド: | ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. |
シノニム: | ADP-ribosylation factor-like 3 |
UniProt Protein Function: | ARL3: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. Belongs to the small GTPase superfamily. Arf family. |
UniProt Protein Details: | Protein type:Cytoskeletal; Cell cycle regulation; G protein, monomeric; G protein, monomeric, ARF Chromosomal Location of Human Ortholog: 10q23.3 Cellular Component: Golgi membrane; Golgi apparatus; centrosome; cytoplasmic microtubule; spindle microtubule; midbody; nucleus; photoreceptor connecting cilium Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; microtubule binding; metal ion binding Biological Process: photoreceptor cell development; protein transport; smoothened signaling pathway; metabolic process; small GTPase mediated signal transduction; organelle organization and biogenesis; intraflagellar transport; cytokinesis; post-Golgi vesicle-mediated transport; kidney development |
NCBI Summary: | ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008] |
UniProt Code: | P36405 |
NCBI GenInfo Identifier: | 543851 |
NCBI Gene ID: | 403 |
NCBI Accession: | P36405.2 |
UniProt Secondary Accession: | P36405,Q53X83, Q5JSM2, B2R6C7, |
UniProt Related Accession: | P36405 |
Molecular Weight: | 182 |
NCBI Full Name: | ADP-ribosylation factor-like protein 3 |
NCBI Synonym Full Names: | ADP-ribosylation factor-like 3 |
NCBI Official Symbol: | ARL3 |
NCBI Official Synonym Symbols: | ARFL3 |
NCBI Protein Information: | ADP-ribosylation factor-like protein 3; ARF-like 3 |
UniProt Protein Name: | ADP-ribosylation factor-like protein 3 |
Protein Family: | ADP-ribosylation factor-like protein |
UniProt Gene Name: | ARL3 |
UniProt Entry Name: | ARL3_HUMAN |