ARHGEF2 Antibody (PACO05711)
- SKU:
- PACO05711
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ARHGEF2 Antibody (PACO05711) |
抗体コード: | PACO05711 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the Internal region of human Lfc. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | ARHGEF2; KIAA0651; LFP40; Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40 |
UniProt Protein Function: | ARHGEF2: a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: cell soma; cytoplasm; cytoplasmic membrane-bound vesicle; cytoskeleton; cytosol; dendritic shaft; focal adhesion; Golgi apparatus; microtubule; protein complex; spindle; tight junction; vesicle Molecular Function:microtubule binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; transcription factor binding; zinc ion binding Biological Process: actin filament organization; activation of NF-kappaB transcription factor; cell division; cell morphogenesis; establishment of mitotic spindle orientation; innate immune response; intracellular protein transport; mitosis; negative regulation of microtubule depolymerization; negative regulation of neurogenesis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of cell proliferation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction |
NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009] |
UniProt Code: | Q92974 |
NCBI GenInfo Identifier: | 205830906 |
NCBI Gene ID: | 9181 |
NCBI Accession: | Q92974.4 |
UniProt Secondary Accession: | Q92974,O75142, Q15079, Q5VY92, Q8TDA3, Q8WUG4, Q9H023 D3DVA6, |
UniProt Related Accession: | Q92974 |
Molecular Weight: | 108,242 Da |
NCBI Full Name: | Rho guanine nucleotide exchange factor 2 |
NCBI Synonym Full Names: | Rho/Rac guanine nucleotide exchange factor 2 |
NCBI Official Symbol: | ARHGEF2 |
NCBI Official Synonym Symbols: | GEF; P40; GEFH1; LFP40; GEF-H1 |
NCBI Protein Information: | rho guanine nucleotide exchange factor 2 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 2 |
UniProt Synonym Protein Names: | Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40 |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF2 |
UniProt Entry Name: | ARHG2_HUMAN |