ARHGAP22 Antibody (PACO04860)
- SKU:
- PACO04860
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ARHGAP22 Antibody |
抗体コード: | PACO04860 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human |
免疫原: | synthesized peptide derived from the C-terminal region of human ARHGAP22. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | ARHGAP22; RHOGAP2; Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22 |
UniProt Protein Function: | ARHGAP22: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 10q11.22 Cellular Component: cytosol; focal adhesion Molecular Function:GTPase activator activity; protein binding Biological Process: regulation of small GTPase mediated signal transduction |
NCBI Summary: | This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q7Z5H3 |
NCBI GenInfo Identifier: | 74750129 |
NCBI Gene ID: | 58504 |
NCBI Accession: | Q7Z5H3.1 |
UniProt Secondary Accession: | Q7Z5H3,O00152, Q6ZSB0, A0AVP7, A5YM75, B4DED8, B9EGA0 C9JDM2, |
UniProt Related Accession: | Q7Z5H3 |
Molecular Weight: | 77,457 Da |
NCBI Full Name: | Rho GTPase-activating protein 22 |
NCBI Synonym Full Names: | Rho GTPase activating protein 22 |
NCBI Official Symbol: | ARHGAP22 |
NCBI Official Synonym Symbols: | RhoGAP2; RhoGap22 |
NCBI Protein Information: | rho GTPase-activating protein 22 |
UniProt Protein Name: | Rho GTPase-activating protein 22 |
UniProt Synonym Protein Names: | Rho-type GTPase-activating protein 22 |
Protein Family: | Rho GTPase-activating protein |
UniProt Gene Name: | ARHGAP22 |
UniProt Entry Name: | RHG22_HUMAN |