APOC3 Antibody, Biotin conjugated (PACO33195)
- SKU:
- PACO33195
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | APOC3 Antibody, Biotin conjugated (PACO33195) |
抗体コード: | PACO33195 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Apolipoprotein C-III protein (21-99AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
シノニム: | Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3), APOC3 |
UniProt Protein Function: | APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Lipid-binding; Secreted Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: chylomicron; early endosome; extracellular region; extracellular space Molecular Function:cholesterol binding; enzyme regulator activity; lipase inhibitor activity; phospholipid binding Biological Process: cholesterol efflux; cholesterol homeostasis; G-protein coupled receptor protein signaling pathway; lipoprotein metabolic process; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; phospholipid efflux; regulation of Cdc42 protein signal transduction; retinoid metabolic process; reverse cholesterol transport; triacylglycerol catabolic process; triacylglycerol metabolic process Disease: Apolipoprotein C-iii Deficiency |
NCBI Summary: | Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P02656 |
NCBI GenInfo Identifier: | 114026 |
NCBI Gene ID: | 345 |
NCBI Accession: | P02656.1 |
UniProt Secondary Accession: | P02656,Q08E83, Q6Q786, |
UniProt Related Accession: | P02656 |
Molecular Weight: | 10,852 Da |
NCBI Full Name: | Apolipoprotein C-III |
NCBI Synonym Full Names: | apolipoprotein C3 |
NCBI Official Symbol: | APOC3 |
NCBI Official Synonym Symbols: | HALP2; APOCIII |
NCBI Protein Information: | apolipoprotein C-III |
UniProt Protein Name: | Apolipoprotein C-III |
UniProt Synonym Protein Names: | Apolipoprotein C3 |
Protein Family: | Apolipoprotein |
UniProt Gene Name: | APOC3 |
UniProt Entry Name: | APOC3_HUMAN |