APOBEC3A Antibody (PACO25002)
- SKU:
- PACO25002
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | APOBEC3A Antibody (PACO25002) |
抗体コード: | PACO25002 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A protein (1-199AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. |
シノニム: | DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.-) (Phorbolin-1), APOBEC3A |
UniProt Protein Function: | APOBEC3A: a single-stranded DNA cytidine deaminase involved in foreign DNA clearance with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic C-to-U hypermutation in nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Interacts with AGO2. Interacts with TRIB3. Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. Up-regulated by interferon and CpG single-stranded DNA (at protein level). Belongs to the cytidine and deoxycytidylate deaminase family. 2 isoforms of the human protein are produced by alternative initiation. |
UniProt Protein Details: | Protein type:EC 3.5.4.-; Hydrolase Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytoplasm; nucleus Molecular Function:cytidine deaminase activity; deoxycytidine deaminase activity; protein binding Biological Process: defense response to virus; innate immune response; negative regulation of viral genome replication |
NCBI Summary: | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |
UniProt Code: | P31941 |
NCBI GenInfo Identifier: | 12644206 |
NCBI Gene ID: | 200315 |
NCBI Accession: | P31941.3 |
UniProt Secondary Accession: | P31941,Q12807, Q5JZ93, Q9UH18, A0AVM1, |
UniProt Related Accession: | P31941 |
Molecular Weight: | 23kDa |
NCBI Full Name: | DNA dC-> |
NCBI Synonym Full Names: | apolipoprotein B mRNA editing enzyme catalytic subunit 3A |
NCBI Official Symbol: | APOBEC3A |
NCBI Official Synonym Symbols: | A3A; ARP3; PHRBN; bK150C2.1 |
NCBI Protein Information: | DNA dC->dU-editing enzyme APOBEC-3A |
UniProt Protein Name: | DNA dC->dU-editing enzyme APOBEC-3A |
UniProt Synonym Protein Names: | Phorbolin-1 |
Protein Family: | DNA dC->dU-editing enzyme |
UniProt Gene Name: | APOBEC3A |