APOBEC1 Antibody, HRP conjugated (PACO57661)
- SKU:
- PACO57661
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | APOBEC1 Antibody, HRP conjugated (PACO57661) |
抗体コード: | PACO57661 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human C->U-editing enzyme APOBEC-1 protein (1-172AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. |
シノニム: | C->U-editing enzyme APOBEC-1 (EC 3.5.4.36) (Apolipoprotein B mRNA-editing enzyme 1) (HEPR) (mRNA(cytosine(6666)) deaminase 1), APOBEC1 |
UniProt Protein Function: | Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Ref.8 |
UniProt Protein Details: | Cofactor: Zinc By similarity. Subunit structure: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP. Ref.6 Ref.7 Subcellular location: Cytoplasm Ref.9. Tissue specificity: Expressed exclusively in the small intestine. Sequence similarities: Belongs to the cytidine and deoxycytidylate deaminase family. |
NCBI Summary: | This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] |
UniProt Code: | P41238 |
NCBI GenInfo Identifier: | 61743957 |
NCBI Gene ID: | 339 |
NCBI Accession: | NP_001635 |
UniProt Related Accession: | P41238 |
Molecular Weight: | 28kDa |
NCBI Full Name: | C->U-editing enzyme APOBEC-1 isoform a |
NCBI Synonym Full Names: | apolipoprotein B mRNA editing enzyme catalytic subunit 1 |
NCBI Official Symbol: | APOBEC1 |
NCBI Official Synonym Symbols: | BEDP; HEPR; CDAR1; APOBEC-1 |
NCBI Protein Information: | C->U-editing enzyme APOBEC-1 |
UniProt Protein Name: | C->U-editing enzyme APOBEC-1 |
UniProt Synonym Protein Names: | Apolipoprotein B mRNA-editing enzyme 1; HEPR |
Protein Family: | APOBEC1 complementation factor |
UniProt Gene Name: | APOBEC1 |
UniProt Entry Name: | ABEC1_HUMAN |