APLNR Antibody, HRP conjugated (PACO24979)
- SKU:
- PACO24979
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | APLNR Antibody, HRP conjugated (PACO24979) |
抗体コード: | PACO24979 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Apelin receptor protein (309-380AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. |
シノニム: | Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11), APLNR, AGTRL1 APJ |
UniProt Protein Function: | AGTRL1: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q12 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; regulation of body fluid levels; heart development; gastrulation |
NCBI Summary: | This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009] |
UniProt Code: | P35414 |
NCBI GenInfo Identifier: | 543823 |
NCBI Gene ID: | 187 |
NCBI Accession: | P35414.1 |
UniProt Related Accession: | P35414 |
Molecular Weight: | 380 |
NCBI Full Name: | Apelin receptor |
NCBI Synonym Full Names: | apelin receptor |
NCBI Official Symbol: | APLNR |
NCBI Official Synonym Symbols: | APJ; APJR; HG11; AGTRL1 |
NCBI Protein Information: | apelin receptor; APJ receptor; HG11 orphan receptor; APJ (apelin) receptor; angiotensin receptor-like 1; G protein-coupled receptor APJ; G-protein coupled receptor APJ; angiotensin II receptor-like 1; G-protein coupled receptor HG11 |
UniProt Protein Name: | Apelin receptor |
UniProt Synonym Protein Names: | Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11 |
Protein Family: | Apelin receptor |
UniProt Gene Name: | APLNR |
UniProt Entry Name: | APJ_HUMAN |